Higher ETV5 Expression Associates With Poor 5-Florouracil-Based Adjuvant Therapy Response in Colon Cancer

Discovery of markers predictive for 5-Fluorouracil (5-FU)-based adjuvant chemotherapy (adjCTX) response in patients with locally advanced stage II and III colon cancer (CC) is necessary precise identification potential therapy responders. PEA3 subfamily ETS transcription factors (ETV1, ETV4, ETV5) are upregulated multiple cancers including cancers. However, the underlying epigenetic mechanism regulating their overexpression as well role predicting largely unexplored. In this study, using gene expression methylation data from The Cancer Genome Atlas (TCGA) project, we showed that promoter DNA negatively correlates ETV4 ( ? = ?0.17, p 5.6 × 10 –3 ) positively ETV5 0.22, 1.43 –4 tissue. Further, our analysis 1,482 five different cohorts revealed higher associates shorter relapse-free survival (RFS) adjCTX treated (Hazard ratio 2.09–5.43, 0.004–0.01). present study suggests a strong biomarker 5-FU-based II/III CC patients.